Substituted biphenyl GPR40 modulators

US8030354B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Sean P. Brown · Craydon Court, US
• Qiong Cao · Boston, US
• Paul John Dransfield · Arlington, US
• Xiaohui Du · Foster City, US
• Zice Fu · Foster City, US
• Jonathan Houze · Cambridge, US
• Xian Yun Jiao · San Mateo, US
• Yong-Jae Kim · Foster City, US
• Todd J. Kohn · Thousand Oaks, US
• SuJen Lai · Burlingame, US
• An-Rong Li · Mill Valley, US
• Daniel C. H. Lin · Redwood City, US
• Jiwen Liu · Winston-Salem, US
• Jian Luo · Palo Alto, US
• Julio C. Medina · Redwood City, US
• Jeffrey D. Reagan · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Margrit Schwarz · Redwood City, US
• Wang Shen · San Mateo, US
• Yongli Su · Foster City, US
• Gayathri Swaminath · Brisbane, US
• Marc Vimolratana · New York, US
• Yingcai Wang · Millbrae, US
• Yumei Xiong · Palo Alto, US
• Li-Xi Yang · San Francisco, US
• Ming Yu · Shaoxing, CN
• Jie Zhang · Sunnyvale, US
• Liusheng Zhu · Foster City, US

Key dates

• Filing date: Oct 3, 2008
• Grant date: Oct 4, 2011
• Expiry date: Feb 3, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.