N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
US8030356B2 · kind B2 · utility
31Cited by
4References
23Claims
0Family size
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Key dates
| Filing date | Mar 16, 2007 |
| Grant date | Oct 4, 2011 |
| Priority date | — |
| Expiry date | Aug 1, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.