Free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and method of preparation and use thereof
US8030482B2 · kind B2 · utility
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Key dates
| Filing date | Jan 11, 2008 |
| Grant date | Oct 4, 2011 |
| Priority date | — |
| Expiry date | Apr 2, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J43/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy to visualize the exchange, distribution, and trafficking of free cholesterol between living cells and to monitor the movement of free cholesterol between ordered and disordered lipid domains in membranes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.