1,4 diamino bicyclic retigabine analogues as potassium channel modulators

US8030518B2 · kind B2 · utility

Assignee

• Valeant Pharmaceuticals International, Inc. · US

Inventors

• Huanming Chen · Irvine, US
• Jianlan Song · Cerritos, US
• Jean-Michel Vernier · Laguna Niguel, US
• Jim Zhen Wu · Shanghai, CN

Key dates

• Filing date: Nov 28, 2007
• Grant date: Oct 4, 2011
• Expiry date: Jun 14, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to compounds of formula I,where G is —O—, —S—, —C(g1)(g2)-, or —NH—, and n=1, 2, or 3. Such compounds modulate potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is seizure disorders.