Methods of enhancing radiation effects with metal nanoparticles
US8033977B2 · kind B2 · utility
30Cited by
25References
34Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 31, 2009 |
| Grant date | Oct 11, 2011 |
| Priority date | — |
| Expiry date | Mar 31, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/93
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.