Patent · US Active

Attenuated nonsegmented negative-sense RNA viruses with reduced mRNA cap methyltransferase activity comprising mutations within conserved domain VI of the large polymerase

US8034355B2 · kind B2 · utility

0Cited by

2References

13Claims

0Family size

Assignee

President and Fellows of Harvard College · US

Inventors

Sean Whelan · Birmingham, US
Jianrong Li · Dublin, US

Key dates

Filing date	Oct 6, 2006
Grant date	Oct 11, 2011
Priority date	—
Expiry date	Apr 17, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2760/20262
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene wherein the mutation reduces viral replication, the methods of manufacturing and methods of use.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.