Use of human prostate cell lines in cancer treatment
US8034360B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 12, 2005 |
| Grant date | Oct 11, 2011 |
| Priority date | — |
| Expiry date | Oct 20, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/884
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention here relates to a product comprised of a cell line or lines intended for use as an allogeneic immunotherapy agent for the treatment of cancer in mammals and humans. All of the studies of cell-based cancer vaccines to date have one feature in common, namely the intention to use cells that contain at least some TSAs and/or TAAs that are shared with the antigens present in patients' tumor. In each case, tumor cells are utilized as the starting point on the premise that only tumor cells will contain TSAs or TAAs of relevance, and the tissue origins of the cells are matched to the tumor site in patients. A primary aspect of the invention is the use of immortalized normal, non-malignant cells as the basis of an allogeneic cell cancer vaccine. Normal cells do not possess TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines. For prostate cancer, for example, a vaccine may be based on one or a combination of different immortalized normal cell lines derived from the prostate. The cell lines are lethally irradiated utilizing gamma irradiation at 50-300 Gy to ensure that they are replication incompetent prior t…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.