Method of increasing biocompatibility of medical device by generating nitric oxide

US8034384B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Mark E. Meyerhoff · Ann Arbor, US
• Melissa M. Reynolds · Fort Collins, US
• Megan Frost · Ypsilanti, US
• Sangyeul Hwang · Ann Arbor, US
• Yiduo Wu · Ann Arbor, US

Key dates

• Filing date: Nov 21, 2007
• Grant date: Oct 11, 2011
• Expiry date: May 18, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J31/1805
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.