Patent · US Active

Engineered cleavage half-domains

US8034598B2 · kind B2 · utility

126Cited by
34References
15Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJun 23, 2009
Grant dateOct 11, 2011
Priority date—
Expiry dateJun 23, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N9/22
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.