Patent · US Active

Enzyme-cleavable prodrug compounds

US8034787B2 · kind B2 · utility

5Cited by

30References

17Claims

0Family size

Assignee

MEDAREX INC. · US

Inventors

Vincent Dubois · Ittre, BE
Ann Marie Fernandez · Brussels, BE
Sanjeev Gangwar · Foster City, US
Evan Lewis · Pacifica, US
Thomas J. Lobl · Valencia, US
Matthew H. Nieder · Seattle, US
Lesley Pickford · Menlo Park, US
Andre Trouet · Winksele, BE
Geoffrey T. Yarranton · Burlingame, US

Key dates

Filing date	Aug 14, 2008
Grant date	Oct 11, 2011
Priority date	—
Expiry date	Feb 13, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.