Bicyclic mGluR5 positive allosteric modulators and methods of making and using same

US8034806B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• P. Jeffrey Conn · Brentwood, US
• Craig W. Lindsley · Brentwood, US
• Charles David Weaver · Franklin, US
• Alice L. Rodriguez · Nashville, US
• Colleen M. Niswender · Nashville, US
• Carrie K. Jones · Nashville, US
• Richard Williams · Newbury Park, US

Key dates

• Filing date: Oct 31, 2008
• Grant date: Oct 11, 2011
• Expiry date: Oct 31, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the invention relates to bicyclic MGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.