Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates

US8034818B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Ahmed Abouabdellah · Paris, FR
• Philippe Burnier · Maisons-Laffitte, FR
• Christian Hoornaert · Antony, FR
• Jean Jeunesse · Paris, FR
• Frederic Puech · Rueil-Malmaison, FR

Key dates

• Filing date: Feb 2, 2007
• Grant date: Oct 11, 2011
• Expiry date: May 20, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Therapeutic uses of a compound corresponding to the general formula (I):in which A=N or CR2; R2=H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR2; B=covalent bond or C1-8-alkylene; R1=optionally substituted heteroaryl; R3=CHR4CONHR5; R4=H or C1-6-alkyl; R5=H, C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-C6-alkylene;in the form of a base, an acid-addition salt, a hydrate or a solvate.