HIV fusion inhibitor peptides with improved biological properties

US8034899B2 · kind B2 · utility

Assignee

• Trimeris, Inc. · US

Inventors

• John J. Dwyer · Stratford, US
• Brian Bray · Graham, US
• Stephen E. Schneider · Morrisville, US
• Huyi Zhang · Garnerville, US
• Nicolai Tvermoes · Durham, US
• Barbara E. Johnston · Raleigh, US
• Paul E. Friedrich · Apex, US

Key dates

• Filing date: Oct 20, 2008
• Grant date: Oct 11, 2011
• Expiry date: Oct 20, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.