Water-soluble thioester and selenoester compounds and methods for making and using the same
US8034900B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Dec 30, 2003 |
| Grant date | Oct 11, 2011 |
| Priority date | — |
| Expiry date | Nov 16, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Water-soluble thioester and selenoester compounds, their generators, as well as methods for making and using the same, are provided. The subject thioester and selenoester compounds are characterized by including an amino acid synthon having a C-terminal group bonded to a water-soluble polymer through a thioester or selenoester linkage. Solid phase resins and protocols for generating the subject compounds are also provided. The subject water soluble thioester and selenoester compounds and generators find use in a variety of different applications, including thioester or selenoester mediated chemical ligation reactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.