Methods of manufacturing crystalline forms of rapamycin analogs

US8034926B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Shekhar Viswanath · Maryland Heights, US
• Larry Bartelt · Highland Park, US
• Robert Leanna · Grayslake, US
• Michael Dolberg Rasmussen · Kenosha, US
• Madhup K. Dhaon · Mundelein, US
• Rodger F. Henry · Park City, US
• Thomas B. Borchardt · Kenosha, US
• Shuang Chen · Gurnee, US
• Geoff G. Zhang · Vernon Hills, US

Key dates

• Filing date: Sep 20, 2010
• Grant date: Oct 11, 2011
• Expiry date: Sep 20, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.