Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions

US8034941B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Eckhardt · Hannover, DE
• Norbert Hauel · Schemmerhofen, DE
• Elke Langkopf · Biberach an der Riß, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Iris Kauffmann-Hefner · Biberach an der Riß, DE
• Mohammad Tadayyon · Hertford, GB
• Michael Mark · Biberach an der Riß, DE

Key dates

• Filing date: Jun 23, 2009
• Grant date: Oct 11, 2011
• Expiry date: Aug 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formulawherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).