Patent · US Active

Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors

US8034969B2 · kind B2 · utility

0Cited by

8References

12Claims

0Family size

Assignee

The NutraSweet Company · US

Inventors

Indra Prakash · Alpharetta, US
Kenneth E. Furlong · Statesboro, US
Handley E. Jackson, III · North Augusta, US

Key dates

Filing date	May 12, 2010
Grant date	Oct 11, 2011
Priority date	—
Expiry date	May 12, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K5/06113
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.