Method of using gold nanorods-siRNA complexes

US8035016B2 · kind B2 · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Earl J. Bergey · South Dayton, US
• Adela Bonoiu · Tonawanda, US
• Supriya Mahajan · Amherst, US
• Paras N. Prasad · Williamsville, US
• Indrajit Roy · Amherst, US
• Stanley A. Schwartz · East Amherst, US
• Ken-Tye Yong · Tonawanda, US

Key dates

• Filing date: Sep 8, 2009
• Grant date: Oct 11, 2011
• Expiry date: Sep 8, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/773
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized gold nanorods (GNRs). The RNA polynucleotides are not covalently bound to the surface functionalized GNRs. The method involves inhibiting expression of a target gene in an individual. The method is performed by administering to the individual an effective amount of a composition containing surface functionalized GNRs electrostatically complexed with RNA polynucleotides, such as siRNA, that can inhibit expression of the target gene via RNAi. The siRNA is not covalently bound to the surface functionalized GNRs.