Methods for forming dyed microspheres and populations of dyed microspheres
US8038734B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 11, 2005 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | Apr 21, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/585
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.