High-viscosity hyaluronic acid compositions to treat myocardial conditions

US8038991B1 · kind B1 · utility

Assignee

• Abbott Cardiovascular Systems, Inc. · US

Inventors

• John Stankus · Plano, US
• Eugene T. Michal · San Francisco, US
• Mikael Trollsas · San Jose, US
• Brandon Katz · Saratoga, US
• Shubhayu Basu · Anaheim, US

Key dates

• Filing date: Nov 1, 2007
• Grant date: Oct 18, 2011
• Expiry date: May 14, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of single component bioscaffolding systems formed of a hydrogel such as hyaluronic acid or salt thereof are described. The hyaluronic acid or salt thereof may be dissolved in a buffer, plasma, or combination thereof to minimize adverse immunogenic responses when applied to a treatment site. Additionally, the hydrogel component includes stem cells to facilitate angiogenesis or facilitate tissue repair and/or regeneration of ischemic tissue, particularly in compromised cardiac tissue. The bioscaffolding may also be formed on a stent or a cardiac medical device.