Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection

US8039001B2 · kind B2 · utility

Assignee

• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Robert Garcea · Boulder, US
• Renee Finnen · Denver, US

Key dates

• Filing date: Apr 3, 2009
• Grant date: Oct 18, 2011
• Expiry date: Jul 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of the present invention provide compositions including a complexes of papillomavirus capsid polypeptide L2 and polypeptide including an immunotherapeutic epitope, and GST fusions thereof. Other embodiments also provide complexes comprising chimeras of papillomavirus L2 polypeptides non-covalently associated with papillomavirus L1 polypeptides, and GST fusions thereof. These compositions may be used to elicit immune responses in a patient to papillomavirus. Therapeutic and prophylactic vaccines for the prevention and treatment of viral infection, especially papillomavirus infection and cervical cancers and warts associated therewith, made from compositions of this invention, are also disclosed. Nucleic acids and expression vectors coding for compositions are also disclosed.