Signal amplification using a synthetic zymogen
US8039228B2 · kind B2 · utility
3Cited by
3References
3Claims
0Family size
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Key dates
| Filing date | Sep 2, 2004 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | Oct 5, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/581
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is modified by a protein produced by a microorganism, the enzyme is activated. The zymogens can be used to amplify detection assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.