Methods for enhanced production of bone morphogenetic proteins
US8039231B2 · kind B2 · utility
8Cited by
6References
47Claims
0Family size
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Key dates
| Filing date | Apr 16, 2009 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | May 2, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.