Mutated HOXB4 proteins with improved stability, and methods of use thereof
US8039436B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | May 30, 2008 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | Nov 12, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A polypeptide, the amino acid sequence of which comprises a sequence as set forth in SEQ ID NO:2, including at least one mutation within the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.