Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US8039443B2 · kind B2 · utility
4Cited by
41References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2004 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | Jun 18, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.