Bicyclic lactam factor VIIa inhibitors useful as anticoagulants

US8039506B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Nicholas R. Wurtz · Pennington, US
• Eldon Scott Priestley · Yardley, US
• Daniel L. Cheney · Ringoes, US
• Xiaojun Zhang · Hopewell, US
• Brandon Parkhurst · Indianapolis, US
• Vladimir Ladziata · Ewing, US

Key dates

• Filing date: Dec 17, 2007
• Grant date: Oct 18, 2011
• Expiry date: May 23, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.