Human synthetic single-chain antibodies directed against the common epitope of mutant P53 and their uses
US8039594B2 · kind B2 · utility
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Key dates
| Filing date | Mar 23, 2006 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | May 27, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Isolated polypeptides, isolated polynucleotides or expression vectors encoding same, viral display vehicles which can be specifically bind an exposed epitope shared by mutant, but not wild type, p53 protein are provided. Also provided are methods of inducing apoptosis and treating cancer as well as diagnosing a p53-related cancer using the isolated polypeptides uncovered by the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.