Tetrahydrofuro[3,2-b] pyrrol-3-one intermediates

US8039641B2 · kind B2 · utility

Assignee

• Amura Therapeutics Limited · GB

Inventors

• Martin Quibell · Cambridge, GB
• James Nally · Cambridge, GB
• Lee Patient · Linton, US
• Yikang Wang · Cambridge, GB
• Claudio Dagostin · Cambridge, GB
• John Paul Watts · Cambridge, GB

Key dates

• Filing date: Jan 8, 2009
• Grant date: Oct 18, 2011
• Expiry date: Oct 12, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula (IVa), where R48 is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Va); and (ii) converting said compound of formula (Va) to a compound of formula (Ia) or (Ic); or (B) (i) treating a compound of formula (IVb), where R48 is alkyl or tosyl, with an oxidizing agent to form a compound of formula (Vb); and (ii) converting said compound of formula (Vb) to a compound of formula (Ib) or (Id).