Process for producing phosphine oxide vitamin D precursors
US8039676B2 · kind B2 · utility
0Cited by
4References
19Claims
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Inventor
Key dates
| Filing date | May 29, 2008 |
| Grant date | Oct 18, 2011 |
| Priority date | — |
| Expiry date | Jul 31, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for producing a compound of the formula:including reacting of a compound of the formula:with diphenyl phosphine oxide using a binary phase reaction mixture including diphenyl phosphine oxide in an organic solvent, a basic aqueous solution, and a phase transfer catalyst, to obtain the compound of formula 1,wherein Ph is phenyl, X1 and X2 are both hydrogen or X1 and X2 taken together are CH2, R1 is a protecting group, R2 is fluorine, hydrogen, or OR3, wherein R3 is a protecting group, and the squiggly line represents a bond that results in the adjacent double bond being in either the E or Z configuration, is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.