Methods and uses of leptin in immune modulation
US8043619B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Oct 8, 2004 |
| Grant date | Oct 25, 2011 |
| Priority date | — |
| Expiry date | Jun 12, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/2264
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes the use of leptin for the immune modulation of the Th1/Th2 response. One aspect of the invention provides for a shift in the Th1/Th2 cell balance towards pro-inflammatory cytokine producing cells. This shift results from an increase in the levels, expression and/or the activity of leptin. Another aspect of the invention provides for a shift in the Th1/Th2 cell balance towards anti-inflammatory cytokine producing cells. This shift results from a decrease in the levels, expression and/or the activity of leptin. The shifting of the Th1/Th2 balance provides a method for the treatment of a variety of diseases and disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.