Immunogenic peptides for the treatment of prostate and breast cancer

US8043623B2 · kind B2 · utility

Assignee

• The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · US

Inventors

• Jay A. Berzofsky · Bethesda, US
• SangKon Oh · Baltimore, US
• Ira H. Pastan · Potomac, US

Key dates

• Filing date: Apr 27, 2009
• Grant date: Oct 25, 2011
• Expiry date: Jan 5, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2239/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed.