Patent · US Active

Process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

US8044196B2 · kind B2 · utility

0Cited by

2References

5Claims

0Family size

Assignee

Jubilant Organosys Limited · IN

Inventors

Jwalant A. Shastri · Noida, IN
Akshat Bhatnagar · Jamkhed, IN
Rajesh Kumar Thaper · Jammu, IN
Sushil Kumar Dubey · Noida, IN

Key dates

Filing date	Jul 14, 2004
Grant date	Oct 25, 2011
Priority date	—
Expiry date	Jun 9, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D333/38
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed is a process for producing pure form of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. The process comprises of reacting 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile with N-methyl piperazine in conjunction with N-methylpiperazine acid salt, to produce 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine. Also disclosed is a process for obtaining the Polymorphic Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine by crystallizing the crude 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine in a mixture of solvents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.