Patent · US Active

Sirtuin modulating compounds

US8044198B2 · kind B2 · utility

24Cited by

6References

10Claims

0Family size

Assignee

Sirtris Pharmaceuticals, Inc. · US

Inventors

Joseph J. Nunes · Andover, US
Jill C. Milne · Brookline, US
Jean E. Bemis · Arlington, US
Roger Xie · Westborough, US
Chi B. Vu · Cambridge, US
Pui Yee Ng · Waltham, US
Jeremy S. Disch · Natick, US

Key dates

Filing date	Feb 15, 2008
Grant date	Oct 25, 2011
Priority date	—
Expiry date	Jun 30, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.