Method and apparatus for sample injection in liquid chromatography
US8047060B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 31, 2006 |
| Grant date | Nov 1, 2011 |
| Priority date | — |
| Expiry date | Feb 25, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T137/86863
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.