Quantitative non-invasive method for detecting degree of malignancy in tumors and application thereof
US8047993B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 6, 2005 |
| Grant date | Nov 1, 2011 |
| Priority date | — |
| Expiry date | Aug 4, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B8/04
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Disclosed is a method for detecting the degree of malignancy in tumors noninvasively, which comprises the steps of: using a Power Doppler ultrasound unit to scan a tumor and capture sequential color imagines in a complete heartbeat cycle, and choosing an area of interest (AREA_ROI) from the images; labeling pixels reflecting signals of bloodflow in the imagines during one heartbeat cycle to contour an area of tumor blood vessels (AREA_vessel); calculating a difference of PDVI between maximal systolic pressure and diastolic pressure during the heartbeat cycle to obtain tumor differential vascularity index (TDVI), in which PDVI is the ratio obtained by dividing pixels of AREA_vessel by a total area in the section of AREA_ROI; and determining the degree of malignancy by the TDVI. The method of the present invention can be applied to monitor the response of tumor to clinical treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.