Methods and apparatus for creating particle derivatives of HDL with reduced lipid content

US8048015B2 · kind B2 · utility

Assignee

• HDL Therapeutics, Inc. · US

Inventors

• Marc Bellotti · Libertyville, US
• H. Bryan Brewer · Potomac, US
• Hassibullah Akeefe · Antioch, US
• Adam Paul Conner · Livermore, US
• Timothy Jon Perlman · Arlington, US

Key dates

• Filing date: Mar 24, 2008
• Grant date: Nov 1, 2011
• Expiry date: Oct 27, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/775
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.