Tissue ablation with irreversible electroporation

US8048067B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Rafael V. Davalos · Blacksburg, US
• Boris Rubinsky · Givatayim, IL

Key dates

• Filing date: Dec 21, 2004
• Grant date: Nov 1, 2011
• Expiry date: Sep 3, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/327
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.