Method of treating a hematopoietic associated disease or disorder with plasma-depleted, but not erythrocyte-depleted cord blood compositions
US8048619B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 29, 2007 |
| Grant date | Nov 1, 2011 |
| Priority date | — |
| Expiry date | Feb 3, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N5/0641
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.