Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
US8048850B2 · kind B2 · utility
1Cited by
12References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 6, 2003 |
| Grant date | Nov 1, 2011 |
| Priority date | — |
| Expiry date | Apr 12, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.