Antimicrobial compounds and formulations

US8048852B2 · kind B2 · utility

Assignee

• LYTIX BIOPHARMA AS · NO

Inventors

• John Sigurd Svendsen · Tromsø, NO
• Bengt Erik Haug · Kleppestø, NO
• Istvan Marko · Louvain-la-Neuve, BE
• Øystein Rekdal · Tromsø, NO
• Merete Linchausen Skar · Tromsø, NO
• Wenche Stensen · Norheim, NO
• Morten Bøhmer Strøm · Tromsø, NO

Key dates

• Filing date: Apr 20, 2007
• Grant date: Nov 1, 2011
• Expiry date: Aug 29, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilizing microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.