1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups, processes for their preparation and their use as pharmaceuticals

US8048901B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Jochen Goerlitzer · Frankfurt am Main, DE
• Heiner Glombik · Hofheim, DE
• Eugen Falk · Frankfurt am Main, DE
• Dirk Gretzke · Frankfurt am Main, DE
• Stefanie Keil · Frankfurt am Main, DE
• Hans-Ludwig Schaefer · Frankfurt am Main, DE
• Christian Stapper · Mainz, DE
• Wolfgang Wendler · Bad Camberg, DE

Key dates

• Filing date: Jul 10, 2007
• Grant date: Nov 1, 2011
• Expiry date: Sep 30, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I,in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved.