Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

US8048905B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Li Chen · Sha Tin, CN
• Michael Patrick Dillon · Mill Valley, US
• Lichun Feng · Shanghai, CN
• Ronald Charles Hawley · Oakland, US
• Minmin Yang · Nanjing, CN

Key dates

• Filing date: Dec 17, 2008
• Grant date: Nov 1, 2011
• Expiry date: Dec 17, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.