Patent · US Active

Reversed mammalian protein-protein interaction trap

US8048986B2 · kind B2 · utility

3Cited by

7References

14Claims

0Family size

Assignee

VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW · BE

Inventors

Sven Eyckerman · Nazareth, BE
Jan Tavernier · Balegem, BE
Joel Vandekerckhove · Loppem, BE

Key dates

Filing date	Dec 14, 2009
Grant date	Nov 1, 2011
Priority date	—
Expiry date	Dec 14, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to a recombinant receptor, comprising a ligand-binding domain and a signaling domain that comprises a heterologous bait polypeptide, which receptor is inactivated by binding of a prey polypeptide to the heterologous bait peptide, either in presence or absence of a ligand binding to the ligand-binding domain. The receptor is activated by addition of a compound that disrupts the bait-prey interaction. The invention also relates to a method of screening compounds that disrupt compound-compound binding using the recombinant receptor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.