Trisubstituted thiazole compounds, preparations methods, pharmaceutical compositions and medicals uses thereof
US8053581B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 15, 2006 |
| Grant date | Nov 8, 2011 |
| Priority date | — |
| Expiry date | Aug 15, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to 2,4,5-trisubstituted thiazole compounds of formula (I) or all possible isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof for the inhibition of plasma PLTP activity and/or plasma CETP activity, wherein the substituents are as defined in the specification; a process for the preparation of the compounds of formula (I); a pharmaceutical composition comprising the compound of formula (I) and its use for the preparation of a medicament for treatment and/or prevention of diseases associated with the increased plasma PLTP activity and/or the increased plasma CETP activity in a mammal, such as atherosclerosis, cardiovascular diseases and peripheral vascular diseases, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.