Human antibodies specific to KDR and uses thereof
US8057791B2 · kind B2 · utility
1Cited by
1References
4Claims
0Family size
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Key dates
| Filing date | Sep 19, 2008 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Jun 24, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.