Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
US8057821B2 · kind B2 · utility
56Cited by
8References
15Claims
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Key dates
| Filing date | Nov 3, 2004 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Aug 20, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.