Method for treating a brain cancer with ifenprodil
US8058243B2 · kind B2 · utility
41Cited by
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4Claims
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Key dates
| Filing date | Oct 12, 2007 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Jun 7, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A clonogenic neurosphere assay is described that carries out high throughput screens (HTS) to identify potent and/or selective modulators of proliferation, differentiation and/or renewal of neural precursor cells, neural progenitor cells and/or self-renewing and multipotent neural stem cells (NSCs). Compositions comprising the identified modulators and methods of using the modulators and compositions, in particular to treat neurological disorders (e.g. brain or CNS cancer) or damage are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.