Patent · US Active

Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists

US8058259B2 · kind B2 · utility

8Cited by

82References

19Claims

0Family size

Assignee

University of Virginia Patent Foundation · US

Inventors

Robert D. Thompson · Charlottesville, US
Anthony Beauglehole · Charlottesville, US
Frank Schmidtmann · Charlottesville, US
Jayson M. Rieger · Charlottesville, US

Key dates

Filing date	Dec 18, 2008
Grant date	Nov 15, 2011
Priority date	—
Expiry date	Mar 30, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P27/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.