Patent · US Active

Proteasome inhibitors and methods of using the same

US8058262B2 · kind B2 · utility

5Cited by

30References

82Claims

0Family size

Assignee

Cephalon LLC · US

Inventors

Raffaella Bernardini · Calci, IT
Alberto Bernareggi · Vimercate, IT
Paolo G. Cassara · Monza, IT
Sankar Chatterjee · Lansdowne, US
Germano D'Arasmo · Novate Milanese, IT
Sergio De Munari · Milano, IT
Edmondo Ferretti · Ravenna, IT
Mohamed Iqbal · Malvern, US
Ernesto Menta · Parma, IT
Patricia A. Messina McLaughlin · Glen Mills, US
Ambrogio Oliva · Saronno, IT

Key dates

Filing date	Feb 3, 2011
Grant date	Nov 15, 2011
Priority date	—
Expiry date	Feb 3, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F5/025
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.