HDM2-inhibitor complexes and uses thereof
US8058390B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Apr 23, 2010 |
| Grant date | Nov 15, 2011 |
| Priority date | — |
| Expiry date | Apr 23, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention includes crystallized HDM2 peptides as well as descriptions of the X-ray diffraction patterns of the crystals. The diffraction patterns allow the three dimensional structure of HDM2 to be determined at atomic resolution so that ligand binding sites on HDM2 can be identified and the interactions of ligands with HDM2 amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MDM2 and HDM2 oncoproteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.